Deciphering Multiplicity of HIV-1C Infection: Transmission of Closely Related Multiple Viral Lineages.

ABSTRACT:

Background

A single viral variant is transmitted in the majority of HIV infections. However, about 20% of heterosexually transmitted HIV infections are caused by multiple viral variants. Detection of transmitted HIV variants is not trivial, as it involves analysis of multiple viral sequences representing intra-host HIV-1 quasispecies.

Methodology

We distinguish two types of multiple virus transmission in HIV infection: (1) HIV transmission from the same source, and (2) transmission from different sources. Viral sequences representing intra-host quasispecies in a longitudinally sampled cohort of 42 individuals with primary HIV-1C infection in Botswana were generated by single-genome amplification and sequencing and spanned the V1C5 region of HIV-1C env gp120. The Maximum Like

SUBMITTER: Novitsky V 

PROVIDER: S-EPMC5125632 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature