Dataset Information

Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjogren's Syndrome International Registry.

ABSTRACT:

Purpose

To identify a screening strategy for dry eye patients with a high likelihood of having Sjogren syndrome (SS) through the evaluation of the association of ocular surface tests with the extraocular signs used for the diagnosis of SS.

Design

Multicenter cross-sectional study.

Methods

The Sjogren's International Clinical Collaborative Alliance (SICCA) registry enrolled 3514 participants with SS or possible SS from 9 international academic sites. Ocular surface evaluation included Schirmer I testing, tear breakup time (TBUT), and staining of the cornea (0-6 points) and conjunctiva (0-6 points). Multivariate logistic regression analysis was performed to identify predictive factors for (1) histopathologic changes on labial salivary gland (LSG) biopsies (positive = focus score of ≥1 focus/4 mm²) and (2) positive anti-SSA/B serology.

Results

The adjusted odds of having a positive LSG biopsy were significantly higher among those with an abnormal Schirmer I test (adjusted OR = 1.26, 95% CI 1.05-1.51, P = .014) and positive conjunctival staining (for each additional unit of staining 1.46; 95% CI 1.39-1.53, P < .001) or corneal staining (for each additional unit of staining 1.14; 95% CI 1.08-1.21, P < .001). The odds of having a positive serology were significantly higher among those with an abnormal Schirmer I test (adjusted OR = 1.3; 95% CI 1.09-1.54, P = .004) and conjunctival staining (adjusted OR = 1.51; 95% CI 1.43-1.58, P < .001).

Conclusions

In addition to corneal staining, which was associated with a higher likelihood of having a positive LSG biopsy, conjunctival staining and abnormal Schirmer I testing are of critical importance to include when screening dry eye patients for possible SS, as they were associated with a higher likelihood of having a positive LSG biopsy and serology.

SUBMITTER: Bunya VY

PROVIDER: S-EPMC5147490 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Publications

Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjögren's Syndrome International Registry.

Bunya Vatinee Y VY Bhosai Satasuk Joy SJ Heidenreich Ana Maria AM Kitagawa Kazuko K Larkin Genevieve B GB Lietman Thomas M TM Gaynor Bruce D BD Akpek Esen K EK Massaro-Giordano Mina M Srinivasan M M Porco Travis C TC Whitcher John P JP Shiboski Stephen C SC Criswell Lindsey A LA Shiboski Caroline H CH

American journal of ophthalmology 20160916

<h4>Purpose</h4>To identify a screening strategy for dry eye patients with a high likelihood of having Sjogren syndrome (SS) through the evaluation of the association of ocular surface tests with the extraocular signs used for the diagnosis of SS.<h4>Design</h4>Multicenter cross-sectional study.<h4>Methods</h4>The Sjogren's International Clinical Collaborative Alliance (SICCA) registry enrolled 3514 participants with SS or possible SS from 9 international academic sites. Ocular surface evaluatio ...[more]

PMID: 27644591

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