Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes.

ABSTRACT:

Background

The GII.4 Sydney 2012 strain of human norovirus (HuNoV) is a pandemic strain that is responsible for the majority of norovirus outbreaks in healthcare settings. The function of the non-structural (NS)1-2 protein from HuNoV is unknown.

Results

In silico analysis of human norovirus NS1-2 protein showed that it shares features with the murine NS1-2 protein, including a disordered region, a transmembrane domain and H-box and NC sequence motifs. The proteins also contain caspase cleavage and phosphorylation sites, indicating that processing and phosphorylation may be a conserved feature of norovirus NS1-2 proteins. In this study, RNA transcripts of human and murine norovirus full-length and the disordered region of NS1-2 were transfected into monocytes, and next genera

SUBMITTER: Lateef Z 

PROVIDER: S-EPMC5217272 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature