IL-4-producing ILC2s are required for the differentiation of T_H2 cells following Heligmosomoides polygyrus infection.

ABSTRACT: Immunity to many human and murine gastrointestinal helminth parasites requires interleukin-4 (IL-4)-directed type 2 helper (T_H2) differentiation of CD4⁺ T cells to elicit type-2 immunity. Despite a good understanding of the inflammatory cascade elicited following helminth infection, the initial source of IL-4 is unclear. Previous studies using the rat helminth parasite Nippostronglyus brasiliensis, identified an important role for basophil-derived IL-4 for T_H2 differentiation. However, basophils are redundant for T_H2 differentiation following infection with the natural helminth parasite of mice Heligmosomoides polygyrus, indicating that other sources of IL-4 are required. In this study using H. polygyrus, which is controlled by IL-4-dependent imm

SUBMITTER: Pelly VS 

PROVIDER: S-EPMC5257265 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature