Human Deciduous Teeth Stem Cells (SHED) Display Neural Crest Signature Characters.

ABSTRACT: Human dental tissues are sources of neural crest origin multipotent stem cells whose regenerative potential is a focus of extensive studies. Rational programming of clinical applications requires a more detailed knowledge of the characters inherited from neural crest. Investigation of neural crest cells generated from human pluripotent stem cells provided opportunity for their comparison with the postnatal dental cells. The purpose of this study was to investigate the role of the culture conditions in the expression by dental cells of neural crest characters. The results of the study demonstrate that specific neural crest cells requirements, serum-free, active WNT signaling and inactive SMAD 2/3, are needed for the activity of the neural crest characters in dental cells. Specifically, the

SUBMITTER: Gazarian KG 

PROVIDER: S-EPMC5268458 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature