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Post-treatment control or treated controllers? Viral remission in treated and untreated primary HIV infection.

ABSTRACT: OBJECTIVE(S):An HIV cure will impose aviraemia that is sustained following the withdrawal of antiretroviral therapy (ART). Understanding the efficacy of novel interventions aimed at curing HIV requires characterization of both natural viral control and the effect of ART on viral control after treatment interruption. DESIGN:Analysis of transient viral control in recent seroconverters in the Short Pulse AntiRetroviral Therapy at Acute Seroconversion trial. METHODS:We compared untreated and treated HIV seroconverters (n?=?292) and identified periods of control (plasma HIV RNA?

SUBMITTER: Martin GE 

PROVIDER: S-EPMC5278888 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Post-treatment control or treated controllers? Viral remission in treated and untreated primary HIV infection.

Martin Genevieve E GE   Gossez Morgane M   Williams James P JP   Stöhr Wolfgang W   Meyerowitz Jodi J   Leitman Ellen M EM   Goulder Philip P   Porter Kholoud K   Fidler Sarah S   Frater John J  

AIDS (London, England) 20170201 4

<h4>Objective(s)</h4>An HIV cure will impose aviraemia that is sustained following the withdrawal of antiretroviral therapy (ART). Understanding the efficacy of novel interventions aimed at curing HIV requires characterization of both natural viral control and the effect of ART on viral control after treatment interruption.<h4>Design</h4>Analysis of transient viral control in recent seroconverters in the Short Pulse AntiRetroviral Therapy at Acute Seroconversion trial.<h4>Methods</h4>We compared  ...[more]

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