Post-treatment control or treated controllers? Viral remission in treated and untreated primary HIV infection.

ABSTRACT:

Objective(s)

An HIV cure will impose aviraemia that is sustained following the withdrawal of antiretroviral therapy (ART). Understanding the efficacy of novel interventions aimed at curing HIV requires characterization of both natural viral control and the effect of ART on viral control after treatment interruption.

Design

Analysis of transient viral control in recent seroconverters in the Short Pulse AntiRetroviral Therapy at Acute Seroconversion trial.

Methods

We compared untreated and treated HIV seroconverters (n = 292) and identified periods of control (plasma HIV RNA < 400 copies/ml for ≥16 weeks off therapy) in 7.9% of ART-naive participants, and in 12.0% overall. HIV DNA was measured by qPCR, and HIV-specific CD8 responses were measured by enzyme-linked immuno

SUBMITTER: Martin GE 

PROVIDER: S-EPMC5278888 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature