Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load.

ABSTRACT:

Objective

To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach.

Methods

Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI. Imaging indexes of APOE2 carriers were contrasted to risk-neutral APOE3 homozygotes, and analyses were controlled for age, sex, education, and clinical diagnosis. Additional models examined genotype-specific effects of age on the imaging marker

SUBMITTER: Grothe MJ 

PROVIDER: S-EPMC5304459 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature