Ontology highlight
ABSTRACT:
SUBMITTER: Fu Z
PROVIDER: S-EPMC5328201 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cell reports 20170201 7
Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. Using a mouse model of hypoxia-driven retinal neovascularization, we find that fibroblast growth factor 21 (FGF21) administration suppresses, and FGF21 deficiency worsens, retinal neovessel growth. The protective effect of FGF21 against neovessel growth was abolished in adiponectin (APN)-deficient mice. FGF21 administration also decreas ...[more]