Role of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy.

ABSTRACT:

Background

Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis.

Objectives

To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease.

Materials and methods

258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion.

Results

As compared with ε3/ε3, in ε4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total perip

SUBMITTER: Mastroianno S 

PROVIDER: S-EPMC5332070 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature