CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo.
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ABSTRACT:
SUBMITTER: Mladenov R
PROVIDER: S-EPMC5341865 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo.
Mladenov Radoslav R Hristodorov Dmitrij D Cremer Christian C Gresch Gerrit G Grieger Elena E Schenke Lea L Klose Diana D Amoury Manal M Woitok Mira M Jost Edgar E Brümmendorf Tim H TH Fendel Rolf R Fischer Rainer R Stein Christoph C Thepen Theo T Barth Stefan S
Oncotarget 20161001 41
Fc gamma receptor I (FcγRI, CD64) is a well-known target antigen for passive immunotherapy against acute myeloid leukemia and chronic myelomonocytic leukemia. We recently reported the preclinical immunotherapeutic potential of microtubule associated protein tau (MAP) against a variety of cancer types including breast carcinoma and Hodgkin's lymphoma. Here we demonstrate that the CD64-directed human cytolytic fusion protein H22(scFv)-MAP kills ex vivo 15-50% of CD64+ leukemic blasts derived from ...[more]
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