Identification of endometrial cancer methylation features using combined methylation analysis methods.

ABSTRACT:

Background

DNA methylation is a stable epigenetic mark that is frequently altered in tumors. DNA methylation features are attractive biomarkers for disease states given the stability of DNA methylation in living cells and in biologic specimens typically available for analysis. Widespread accumulation of methylation in regulatory elements in some cancers (specifically the CpG island methylator phenotype, CIMP) can play an important role in tumorigenesis. High resolution assessment of CIMP for the entire genome, however, remains cost prohibitive and requires quantities of DNA not available for many tissue samples of interest. Genome-wide scans of methylation have been undertaken for large numbers of tumors, and higher resolution analyses for a limited number of cancer specimens. Meth

SUBMITTER: Trimarchi MP 

PROVIDER: S-EPMC5344376 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature