Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma.

ABSTRACT: The development of noninvasive imaging techniques for the accurate diagnosis of progressive hepatocellular carcinoma (HCC) is of great clinical significance and has always been desired. Herein, a hepatocellular carcinoma cell-targeting fluorescent magnetic nanoparticle (NP) was obtained by conjugating near-infrared fluorescence to the surface of Fe₃O₄ (NIRF-Fe₃O₄) NPs, followed by coating the lipids consisting of tumoral hepatocytes-targeting polymer (Gal-P₁₂₃). This magnetic NP (GPC@NIRF-Fe₃O₄) with superparamagnetic behavior showed high stability and safety in physiological conditions. In addition, GPC@NIRF-Fe₃O₄ achieved more specific uptake of human liver cancer cells than free Fe₃O₄ NPs. Importantly, with superpara-magnetic iron oxide and strong NIR absorbance, GPC@NIRF-Fe₃O₄ NPs demonstrate prominent tumor-contrasted imaging performance both on fluorescent and T₂-weighted magnetic resonance (MR) imaging modalities in a living body. The relative MR signal enhancement of GPC@NIRF-Fe₃O₄ NPs achieved 5.4-fold improvement compared with NIR-Fe₃O₄ NPs. Therefore, GPC@ NIRF-Fe₃O₄ NPs may be potentially used as a candidate for dual-modal imaging of tumors with information covalidated and directly compared by combining fluorescence and MR imaging.

SUBMITTER: Liang J 

PROVIDER: S-EPMC5358985 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature