The RegA regulon exhibits variability in response to altered growth conditions and differs markedly between Rhodobacter species.

ABSTRACT: The RegB/RegA two-component system from Rhodobacter capsulatus regulates global changes in gene expression in response to alterations in oxygen levels. Studies have shown that RegB/RegA controls many energy-generating and energy-utilizing systems such as photosynthesis, nitrogen fixation, carbon fixation, hydrogen utilization, respiration, electron transport and denitrification. In this report, we utilized RNA-seq and ChIP-seq to analyse the breadth of genes indirectly and directly regulated by RegA. A comparison of mRNA transcript levels in wild type cells relative to a RegA deletion strain shows that there are 257 differentially expressed genes under photosynthetic defined minimal growth medium conditions and 591 differentially expressed genes when grown photosynthetically in a co

SUBMITTER: Schindel HS 

PROVIDER: S-EPMC5359404 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature