Differential requirements for the canonical NF-κB transcription factors c-REL and RELA during the generation and activation of mature B cells.

ABSTRACT: Signaling through the canonical nuclear factor-κB (NF-κB) pathway is critical for the generation and maintenance of mature B cells and for antigen-dependent B-cell activation. c-REL (rel) and RELA (rela) are the downstream transcriptional activators of the canonical NF-κB pathway. Studies of B cells derived from constitutional rel knockout mice and chimeric mice repopulated with rela^-/- fetal liver cells provided evidence that the subunits can have distinct roles during B-cell development. However, the B cell-intrinsic functions of c-REL and RELA during B-cell generation and antigen-dependent B-cell activation have not been determined in vivo. To clarify this issue, we crossed mice with conditional rel and rela alleles individually or in combination to mice that express Cre-reco

SUBMITTER: Milanovic M 

PROVIDER: S-EPMC5360551 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature