Effect of vitamin D₃-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway.

ABSTRACT:

Objective

Vitamin D is essential for the maintenance of calcium homeostasis and bone mineralization; and low serum 25-hydroxyvitamin D (s-25-(OH)D) concentrations are associated with increased bone turnover. However, there is a lack of randomized controlled trials that have investigated the effect of vitamin D treatment on bone turnover in immigrant populations. We aimed to investigate the effect of 16-week daily vitamin D₃ supplementation on bone formation marker serum procollagen type 1 amino-terminal propeptide (P1NP) and bone resorption marker C-terminal crosslinked telopeptide of type I collagen (CTX).

Design

Double-blind, randomized, placebo-controlled trial.

Setting

Immigrant community centers in Oslo, Norway.

Participants

251 healthy adults a

SUBMITTER: Madar AA 

PROVIDER: S-EPMC5365165 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature