Vascular-targeted photothermal therapy of an orthotopic murine glioma model.

ABSTRACT:

Aim

To develop nanoshells for vascular-targeted photothermal therapy of glioma.

Materials & methods

The ability of nanoshells conjugated to VEGF and/or poly(ethylene glycol) (PEG) to thermally ablate VEGF receptor-2-positive endothelial cells upon near-infrared laser irradiation was evaluated in vitro. Subsequent in vivo studies evaluated therapy in mice bearing intracerebral glioma tumors by exposing tumors to near-infrared light after systemically delivering saline, PEG-coated nanoshells, or VEGF-coated nanoshells. The treatment effect was monitored with intravital microscopy and histology.

Results

VEGF-coated but not PEG-coated nanoshells bound VEGF receptor-2-positive cells in vitro to enable targeted photothermal ablation. In vivo, VEGF targeting doubled the prop

SUBMITTER: Day ES 

PROVIDER: S-EPMC5375028 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature