Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes.

ABSTRACT:

Rationale

Leukocyte telomere length (LTL) is a biological marker of aging, and shorter LTL is associated with adverse cardiovascular outcomes. Reduced regenerative capacity has been proposed as a mechanism. Bone marrow-derived circulating progenitor cells are involved in tissue repair and regeneration.

Objective

Main objective of this study was to examine the relationship between LTL and progenitor cells and their impact on adverse cardiovascular outcomes.

Methods and results

We measured LTL by quantitative polymerase chain reaction in 566 outpatients (age: 63±9 years; 76% men) with coronary artery disease. Circulating progenitor cells were enumerated by flow cytometry. After adjustment for age, sex, race, body mass index, smoking status, and previous myocardial infar

SUBMITTER: Hammadah M 

PROVIDER: S-EPMC5376244 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature