Cytotoxic Phyllactone Analogs from the Marine Sponge Phyllospongia papyrecea.

ABSTRACT:

Background

A growing evidence indicates that marine sponge Phyllospongia sp. is one of rich sources of 20, 24-bishomoscalarane sesterterpenes with potent biological activities. In order to search more bioactive 20, 24-bishomoscalarane sesterterpenes for new drug discovery, chemical investigation was carried out on an Indonesian marine sponge P. papyrecea.

Methods

Bioassay-guided fractionation was carried out on its dichloromethane extract. And nine compounds were purified and isolated using HPLC. Their chemical structures were determined by a combination of spectroscopic and spectrometric data, including 1D-, 2D-NMR and HRESI-MS. Their cytotoxic activities were performed on three human tumor cell lines A549, MCF-7 and HeLa using the CCK-8 method.

Results

One new 20, 2

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5384874 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature