Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer.

ABSTRACT:

Background

OPCML belongs to the IgLON family of Ig domain-containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear.

Methods

We assessed expression and biological behavior of OPCML in gastric cancer.

Results

OPCML expression was markedly reduced in tumor tissues and cancer cell lines. Decreased OPCML expression had a significant association with unfavorable tumor stage (p = 0.007) and grading (p < 0.001). Furthermore, the results revealed that OPCML was an independent prognostic factor for overall survival in gastric cancer (p = 0.002). In addition, ectopic expression of OPCML in cancer cells significantly inhibited cell viability (p < 0.01) and colony formation (p < 0.001)

SUBMITTER: Xing X 

PROVIDER: S-EPMC5391589 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature