Human whole blood ¹ H₂ O transverse relaxation with gadolinium-based contrast reagents: Magnetic susceptibility and transmembrane water exchange.

ABSTRACT:

Purpose

To characterize transverse relaxation in oxygenated whole blood with extracellular gadolinium-based contrast reagents by experiment and simulation.

Methods

Experimental measurements of transverse ¹ H₂ O relaxation from oxygenated whole human blood and plasma were made at 1.5 and 3.0 Tesla. Spin-echo refocused and free-induction decays are reported for blood and plasma samples containing four different contrast reagents (gadobenate, gadoteridol, gadofosveset, and gadobutrol), each present at concentrations ranging from 1 to 18 mM (i.e., mmol (contrast reagent (CR))/L (blood)). Monte Carlo simulations were conducted to ascertain the molecular mechanisms underlying relaxation. These consisted of random walks of water molecules in a large ensemble o

SUBMITTER: Wilson GJ 

PROVIDER: S-EPMC5392183 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature