Metabolic effects of oral versus transdermal 17β-estradiol (E₂): a randomized clinical trial in girls with Turner syndrome.

ABSTRACT:

Context

The long-term effects of pure 17β-estradiol (E₂) depending on route of administration have not been well characterized.

Objective

Our objective was to assess metabolic effects of oral vs transdermal (TD) 17β-E₂ replacement using estrogen concentration-based dosing in girls with Turner syndrome (TS).

Patients

Forty girls with TS, mean age 16.7 ± 1.7 years, were recruited.

Design

Subjects were randomized to 17β-E₂ orally or TD. Doses were titrated using mean E₂ concentrations of normally menstruating girls as therapeutic target. E₂, estrone (E₁), and E₁ sulfate (E₁S) were measured by liquid chromatography tandem mass spectrometry and a recombinant cell bioassay; metabolites were measured, and dual-energy x-ray absorptiometry scan and indirect calorimetry

SUBMITTER: Torres-Santiago L 

PROVIDER: S-EPMC5393461 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature