Ontology highlight
ABSTRACT:
SUBMITTER: Greene JM
PROVIDER: S-EPMC5397382 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Mucosal immunology 20161019 3
Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-contact residues are conserved between human and multiple NHP species, three T-cell receptor contact-residue mutations in NHP MR1 diminish binding of human MR1 tetramers to macaque MAITs. Construction of naturally loaded macaque MR1 tetramers facilitated identific ...[more]