Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma.

ABSTRACT: Medulloblastoma (MB) is the most common pediatric malignant brain tumor and patients with high-risk or recurrent MB respond poorly to current therapies, and have a higher related mortality. For this reason, potential molecules related to MB need be identified in order to develop targets for the development of novel therapeutics. In the present study, we compared MB microarray data obtained using different microarray systems and significant targets were selected by gene annotation and enrichment analysis. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function 'vesicle' were identified and one of these proteins, synaptosomal-associated protein 25 (SNAP25), was found to have significantly lower expression levels in MB. In addition

SUBMITTER: Huang CJ 

PROVIDER: S-EPMC5403484 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature