ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

ABSTRACT:

Background

Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD) is unknown.

Objectives

The study goal was to leverage 3 distinct lines of evidence-a family that included individuals with complete (compound heterozygote) ANGPTL3 deficiency, a population based-study of humans with partial (heterozygote) ANGPTL3 deficiency, and biomarker levels in patients with myocardial infarction (MI)-to test whether ANGPTL3 deficiency is associated with lower risk for CAD.

Methods

We assessed coronary atherosclerotic burden in 3 individuals with complete ANGPTL3

SUBMITTER: Stitziel NO 

PROVIDER: S-EPMC5404817 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature