Clinically relevant circulating microRNA profiling studies in pancreatic cancer using meta-analysis.

ABSTRACT:

Background

Pancreatic cancer (PaCa) is the most lethal gastrointestinal (GI) tumor. Although many studies on differentially expressed miRNAs as candidate biomarkers of pancreatic cancer have been published, reliability of these findings generated from investigations performed in single laboratory settings remain unclear.

Results

There were 29 articles with a total of 2,225 patients and 1,618 controls included in this meta-analysis. The pooled sensitivity was 82% (95% CI, 79-85%); the specificity was 85% (95% CI, 79-89%); and area under the curve (AUC) was 0.89 (95% CI, 0.86-0.92). Subgroup analyses indicated that there were significant divergences between Caucasian and Asian subgroups for circulating miRNA analysis.

Materials and methods

To comprehensively investigate

SUBMITTER: Pei Z 

PROVIDER: S-EPMC5410249 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature