Endoscopy-Guided Evaluation of Duodenal Mucosal Permeability in Functional Dyspepsia.

ABSTRACT:

Objectives

The pathophysiology of functional dyspepsia (FD) is not fully understood. Impaired duodenal mucosal integrity characterized by increased mucosal permeability and/or low-grade inflammation was reported as potentially important etiologies. We aimed to determine the utility of a recently developed simple catheterization method to measure mucosal admittance (MA), the inverse of mucosal impedance, for evaluation of duodenal mucosal permeability in patients with FD.

Methods

We conducted two prospective studies. In the first study, duodenal MA of 23 subjects was determined by catheterization during upper endoscopy, and transepithelial electrical resistance (TEER) of duodenal biopsy samples in Ussing chambers was measured to assess the correlation between MA and TEER. In

SUBMITTER: Ishigami H 

PROVIDER: S-EPMC5415894 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature