Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC5418622 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature communications 20170503
Reprogramming has been shown to involve EMT-MET; however, its role in cell differentiation is unclear. We report here that in vitro differentiation of hESCs to hepatic lineage undergoes a sequential EMT-MET with an obligatory intermediate mesenchymal phase. Gene expression analysis reveals that Activin A-induced formation of definitive endoderm (DE) accompanies a synchronous EMT mediated by autocrine TGFβ signalling followed by a MET process. Pharmacological inhibition of TGFβ signalling blocks ...[more]