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T Cells in Celiac Disease.

ABSTRACT: Celiac disease is a human T cell-mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, this review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease.

SUBMITTER: Jabri B 

PROVIDER: S-EPMC5426360 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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T Cells in Celiac Disease.

Jabri Bana B   Sollid Ludvig M LM  

Journal of immunology (Baltimore, Md. : 1950) 20170401 8

Celiac disease is a human T cell-mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, this review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celi  ...[more]

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