Sphingolipids as a new factor in the pathomechanism of preeclampsia - Mass spectrometry analysis.

ABSTRACT: OBJECTIVE(S) AND DESIGN:The aim of the study was to analyse a panel of 11 sphingolipids in plasma and three blood fractions (platelet-poor plasma, platelets and red blood cells) of women with mild preeclampsia. MATERIALS AND METHODS:We recruited 21 women between 25-40 weeks gestation with diagnosed mild preeclampsia to the study group and 36 healthy women with uncomplicated pregnancies, who corresponded with the study group according to gestational age, to the control group. To assess the concentration of 11 sphingolipids in the blood plasma and blood fractions, we used ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC/MS/MS). RESULTS:We showed a significant increase in the concentration of eight sphingolipids in the plasma of women with p

SUBMITTER: Charkiewicz K 

PROVIDER: S-EPMC5438119 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature