Giardia Alters Commensal Microbial Diversity throughout the Murine Gut.

ABSTRACT: Giardia lamblia is the most frequently identified protozoan cause of intestinal infection. Over 200 million people are estimated to have acute or chronic giardiasis, with infection rates approaching 90% in areas where Giardia is endemic. Despite its significance in global health, the mechanisms of pathogenesis associated with giardiasis remain unclear, as the parasite neither produces a known toxin nor induces a robust inflammatory response. Giardia colonization and proliferation in the small intestine of the host may, however, disrupt the ecological homeostasis of gastrointestinal commensal microbes and contribute to diarrheal disease associated with giardiasis. To evaluate the impact of Giardia infection on the host microbiota, we used culture-independent meth

SUBMITTER: Barash NR 

PROVIDER: S-EPMC5442636 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature