Ontology highlight
ABSTRACT:
SUBMITTER: Deleye L
PROVIDER: S-EPMC5469777 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20170613 1
Whole genome amplification (WGA) has become an invaluable tool to perform copy number variation (CNV) detection in single, or a limited number of cells. Unfortunately, current WGA methods introduce representation bias that limits the detection of small CNVs. New WGA methods have been introduced that might have the potential to reduce this bias. We compared the performance of PicoPLEX DNA-Seq (Picoseq), DOPlify, REPLI-g and Ampli-1 WGA for aneuploidy screening and copy number analysis using shall ...[more]