Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα₁₃.

ABSTRACT: The R7 regulator of G protein signaling family (R7-RGS) critically regulates nervous system development and function. Mice lacking all R7-RGS subtypes exhibit diverse neurological phenotypes, and humans bearing mutations in the retinal R7-RGS isoform RGS9-1 have vision deficits. Although each R7-RGS subtype forms heterotrimeric complexes with Gβ₅ and R7-RGS-binding protein (R7BP) that regulate G protein-coupled receptor signaling by accelerating deactivation of G_i/o α-subunits, several neurological phenotypes of R7-RGS knock-out mice are not readily explained by dysregulated G_i/o signaling. Accordingly, we used tandem affinity purification and LC-MS/MS to search for novel proteins that interact with R7-RGS heterotrimers in the mouse brain. Among several pro

SUBMITTER: Scherer SL 

PROVIDER: S-EPMC5473243 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature