Acute liver effects, disposition and metabolic fate of [¹⁴C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.

ABSTRACT: The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with radioactivity still detectable in blood, kidney and liver at 72 h post-dose. Mice dosed with [¹⁴C]-fenclozic acid showed acute centrilobular hepatocellular necrosis, but no other regions of the liver were affected. The majority of the [¹⁴C]-fenclozic acid-related material recovered was found in the urine/aqueous cage wash, (49%) whilst a smaller portion (13%) was eliminated via the faeces. Metabolic profiles for urine, bile and faecal extracts, obtained using liquid chromat

SUBMITTER: Pickup K 

PROVIDER: S-EPMC5489613 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature