Genotyping of HBV and tracking of resistance mutations in treatment-naive patients with chronic hepatitis B.

ABSTRACT:

Background and aims

Resistance mutation analogs to nucleos(t)ides have been described in treatment-naïve patients with chronic hepatitis B (CHB), with clinical implications. The aim of this study was to investigate primary resistance mutations and genotypes circulating in patients naïve to chronic hepatitis B, in the Northern and Northeastern regions of Brazil.

Methods

We conducted a study of resistance mutations and genotypic characterization of hepatitis B virus (HBV) in 189 treatment-naïve patients chronically infected with HBV.

Results

Drug resistance-associated mutations located in the RT domain of the P gene (rtHBV) were found in 6% of the treatment-naïve patients from the Northeastern Region. The mutations were rtA194T, rtL180M + rtM204V, rtS202I, rtM204I, and

SUBMITTER: Pacheco SR 

PROVIDER: S-EPMC5503499 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature