Azathioprine and 6-Mercaptopurine-induced Liver Injury: Clinical Features and Outcomes.

ABSTRACT:

Objective

The objective of the study was to define the clinical, biochemical, and histologic features of liver injury from thiopurines.

Background

Azathioprine (Aza) and 6-mercaptopurine (6-MP) can cause liver injury, but no large series exist.

Methods

Clinical and laboratory data and 6-month outcomes of patients with thiopurine hepatotoxicity from the Drug-Induced Liver Injury Network Prospective Study were analyzed.

Results

Twenty-two patients were identified, 12 due to Aza and 10 due to 6-MP, with a median age of 55 years; the majority were female (68%). Inflammatory bowel disease was the indication in 55%, and the median thiopurine dose was 150 (range, 25 to 300) mg daily. The median latency to onset was 75 (range, 3 to 2584) days. Injury first arose after

SUBMITTER: Bjornsson ES 

PROVIDER: S-EPMC5505863 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature