Enhanced antimicrobial de-escalation for pneumonia in mechanically ventilated patients: a cross-over study.

ABSTRACT:

Background

Antibiotics are commonly administered to hospitalized patients with infiltrates for possible bacterial pneumonia, often leading to unnecessary treatment and increasing the risk for resistance emergence. Therefore, we performed a study to determine if an enhanced antibiotic de-escalation practice could improve antibiotic utilization in mechanically ventilated patients with suspected pneumonia cared for in an academic closed intensive care unit (ICU).

Methods

This was a prospective cross-over trial comparing routine antibiotic management (RAM) and enhanced antimicrobial de-escalation (EAD) performed within two medical ICUs (total 34 beds) at Barnes-Jewish Hospital, an academic referral center. Patients in the EAD group had their antibiotic orders and microbiology re

SUBMITTER: Trupka T 

PROVIDER: S-EPMC5513164 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature