Inter-country variability over time in the mortality of mechanically ventilated patients.

ABSTRACT:

Purpose

Variations in clinical characteristics and management and in the mortality of mechanically ventilated patients have not been sufficiently evaluated. We hypothesized that mortality shows a variability associated with country after adjustment for clinical characteristics and management.

Methods

Analysis of four studies carried out at 6-year intervals over an 18-year period. The studies included 26,024 patients (5183 in 1998, 4968 in 2004, 8108 in 2010, and 7765 in 2016) admitted to 1253 units from 38 countries. The primary outcome was 28-day mortality. We performed analyses using multilevel logistic modeling with mixed-random effects, including country as a random variable. To evaluate the effect of management strategies on mortality, a mediation analysis was performed

SUBMITTER: Penuelas O 

PROVIDER: S-EPMC7222132 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature