Mutation status among patients with sinonasal mucosal melanoma and its impact on survival.

ABSTRACT:

Background

Sinonasal mucosal melanoma (SNMM) comprises <1% of all melanomas and lacks well-characterised molecular markers. Our aim was to determine the frequencies of common mutations and examine their utility as molecular markers in a large series of primary SNMMs.

Methods

SNMM patients seen at our institution from August 1991 through July 2016 were identified. Genomic DNA was extracted from 66 formalin-fixed paraffin-embedded tumours and screened for mutations by direct sequencing. We investigated the association of mutations with clinicopathological features and survival outcomes.

Results

Overall, 41% (27 out of 66) of the SNMMs harboured mutations. BRAF and KIT mutations were identified in 8% (five patients) and 5% (three patients) of SNMMs, respectively, whereas

SUBMITTER: Amit M 

PROVIDER: S-EPMC5518854 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature