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The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition.

ABSTRACT: Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting that inhibition of HIV envelope palmitoylation is one of the mechanisms of antiviral action.

SUBMITTER: Fleta-Soriano E

PROVIDER: S-EPMC5527598 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition.

Fleta-Soriano Eric E Smutná Katarína K Martínez Javier P JP Lorca Oró Cristina C Sadiq S Kashif SK Mirambeau Gilles G Lopez-Iglesias Carmen C Bosch Marta M Pol Albert A Brönstrup Mark M Diez Juana J Meyerhans Andreas A

Antimicrobial agents and chemotherapy 20170725 8

Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting that inhibition of HIV envelope palmitoylation is one of the mechanisms of antiviral action. ...[more]

PMID: 28533249

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