Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.

ABSTRACT:

Introduction

BRCA1-mutated breast carcinomas may have distinct biological features, suggesting the involvement of specific oncogenic pathways in tumor development. The identification of genomic aberrations characteristic for BRCA1-mutated breast carcinomas could lead to a better understanding of BRCA1-associated oncogenic events and could prove valuable in clinical testing for BRCA1-involvement in patients.

Methods

For this purpose, genomic and gene expression profiles of basal-like BRCA1-mutated breast tumors (n = 27) were compared with basal-like familial BRCAX (non-BRCA1/2/CHEK2*1100delC) tumors (n = 14) in a familial cohort of 120 breast carcinomas.

Results

Genome wide copy number profiles of the BRCA1-mutated breast carcinomas in our data appeared heterogeneous.

SUBMITTER: Massink MP 

PROVIDER: S-EPMC5528776 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature