FSH receptor gene p. Thr307Ala and p. Asn680Ser polymorphisms are associated with the risk of polycystic ovary syndrome.

ABSTRACT:

Purpose

The purpose of this study was to investigate whether the follicle-stimulating hormone receptor (FSHR) gene p. Thr307Ala (c.919A>G, rs6165) and p. Asn680Ser (c.2039A>G, rs6166) polymorphisms are associated with susceptibility to polycystic ovary syndrome (PCOS).

Methods

Genotyping was performed in 377 women with PCOS and 388 age-matched controls. Difference in the genotype distribution was assessed using a Fisher's exact or chi-square test, and continuous variables were compared using a Student's t test. To evaluate the association between the presence of PCOS status and SNP, logistic regression analyses were performed.

Results

Linkage disequilibrium between the two polymorphisms was approximately complete (r ² = 99%). The genotype distributions of t

SUBMITTER: Kim JJ 

PROVIDER: S-EPMC5533683 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature