Serum complexed and free prostate specific antigen levels are lower in female elite athletes in comparison to control women.

ABSTRACT:

Background

We hypothesize that prostate specific antigen (PSA), a protein that it is under regulation by androgens, may be differentially expressed in female elite athletes in comparison to control women.

Methods

We conducted a cross-sectional study of 106 female athletes and 114 sedentary age-matched controls.  Serum from these women was analyzed for complexed prostate specific antigen (cPSA) and free prostate specific antigen (fPSA), by fifth generation assays with limits of detection of around 6 and 140 fg/mL, respectively.  A panel of estrogens, androgens and progesterone in the same serum was also quantified by tandem mass spectrometry.  Results: Both components of serum PSA (cPSA and fPSA) were lower in the elite athletes vs the control group (P=0.033 and 0.013, respec

SUBMITTER: Eklund E 

PROVIDER: S-EPMC5539849 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature