Monocytic myeloid-derived suppressor cells regulate T-cell responses against vaccinia virus.

ABSTRACT: Vaccinia virus (VV) can potently activate NK- and T-cell responses, leading to efficient viral control and generation of long-lasting protective immunity. However, immune responses against viral infections are often tightly controlled to avoid collateral damage and systemic inflammation. We have previously shown that granulocytic myeloid-derived suppressor cells (g-MDSCs) can suppress the NK-cell response to VV infection. It remains unknown what regulates T-cell responses to VV infection in vivo. In this study, we first showed that monocytic MDSCs (m-MDSCs), but not g-MDSCs, from VV-infected mice could directly suppress CD4⁺ and CD8⁺ T-cell activation in vitro. We then demonstrated that defective recruitment of m-MDSCs to the site of VV infection in CCR2^-/-

SUBMITTER: Fortin C 

PROVIDER: S-EPMC5544943 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature