Maternal house dust mite exposure during pregnancy enhances severity of house dust mite-induced asthma in murine offspring.

ABSTRACT:

Background

Atopic status of the mother and maternal exposure to environmental factors are associated with increased asthma risk. Moreover, animal models demonstrate that exposure to allergens in strongly sensitized mothers influences offspring asthma development, suggesting that in utero exposures can influence offspring asthma. However, it is unclear whether maternal exposure to common human allergens such as house dust mite (HDM), in the absence of additional adjuvants, influences offspring asthma development.

Objective

We sought to determine whether maternal HDM exposure influences asthma development in offspring.

Methods

Pregnant female mice were exposed to PBS or HDM during pregnancy. Using offspring of PBS- or HDM-exposed mothers, the magnitude of HDM or Aspergi

SUBMITTER: Richgels PK 

PROVIDER: S-EPMC5550362 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature