Enhancing Immune Responses to Cancer Vaccines Using Multi-Site Injections.

ABSTRACT: For a vaccine to be effective it must induce a sufficiently robust and specific immune response. Multi-site injection protocols can increase the titers of rabies virus-neutralizing antibodies. Hypothetically, spreading a vaccine dose across multiple lymphatic drainage regions could also potentiate T cell responses. We used a replication-deficient adenovirus serotype 5-vectored cancer vaccine targeting the melanoma-associated antigen dopachrome tautomerase. Clinically, high numbers of tumor-infiltrating CD8⁺ T cells are a positive prognostic indicator. As such, there is interest in maximizing tumor-specific T cell responses. Our findings confirm a positive correlation between the number of tumor-specific T cells and survival. More importantly, we show for the first time that usin

SUBMITTER: Mould RC 

PROVIDER: S-EPMC5559552 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature