Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study.

ABSTRACT:

Objective

We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes.

Research design and methods

Infants with HLA-DR high-risk genotypes were prospectively followed for diabetes-related autoantibodies. Single nucleotide polymorphisms (SNPs) came from the Illumina ImmunoChip and environmental exposure data were by parental report. Children were followed to age 6 years.

Results

Insulin autoantibodies occurred earlier than GAD antibody (GADA) and then declined, while GADA incidence rose and remained constant (significant in HLA-DR4 but not in the DR3/3 children). The presence of SNPs rs2476601 (PTPN22) and rs2292239 (ERBB3) demonstrated increased risk of both autoantib

SUBMITTER: Krischer JP 

PROVIDER: S-EPMC5566280 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature