Dataset Information

Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.

ABSTRACT:

Objective

To test the hypothesis that 12 months of seal oil omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation will stop the known progression of diabetic sensorimotor polyneuropathy (DSP) in type 1 diabetes mellitus (T1DM).

Methods

Individuals with T1DM and evidence of DSP as determined by a Toronto Clinical Neuropathy Score ≥1 were recruited to participate in a single-arm, open-label trial of seal oil ω-3 PUFA supplementation (10 mL·d^-1; 750 mg eicosapentaenoic acid, 560 mg docosapentaenoic acid, and 1,020 mg docosahexaenoic acid) for 1 year. The primary outcome was the 1-year change in corneal nerve fiber length (CNFL) measured by in vivo corneal confocal microscopy, with sensory and nerve conduction measures as secondary outcomes.

Results

Forty participants (53% female), aged 48 ± 14 years, body mass index 28.1 ± 5.8 with diabetes duration of 27 ± 18 years, were enrolled. At baseline, 23 participants had clinical DSP and 17 did not. Baseline CNFL was 8.3 ± 2.9 mm/mm² and increased 29% to 10.1 ± 3.7 mm/mm² (p = 0.002) after 12 months of supplementation. There was no change in nerve conduction or sensory function.

Conclusions

Twelve months of ω-3 supplementation was associated with increase in CNFL in T1DM.

Clinicaltrialsgovidentifier

NCT02034266.

Classification of evidence

This study provides Class IV evidence that for patients with T1DM and evidence of DSP, 12 months of seal oil omega-3 supplementation increases CNFL.

SUBMITTER: Lewis EJH

PROVIDER: S-EPMC5567321 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.

Lewis Evan J H EJH Perkins Bruce A BA Lovblom Leif E LE Bazinet Richard P RP Wolever Thomas M S TMS Bril Vera V

Neurology 20170517 24

<h4>Objective</h4>To test the hypothesis that 12 months of seal oil omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation will stop the known progression of diabetic sensorimotor polyneuropathy (DSP) in type 1 diabetes mellitus (T1DM).<h4>Methods</h4>Individuals with T1DM and evidence of DSP as determined by a Toronto Clinical Neuropathy Score ≥1 were recruited to participate in a single-arm, open-label trial of seal oil ω-3 PUFA supplementation (10 mL·d<sup>-1</sup>; 750 mg eicosapenta ...[more]

PMID: 28515269

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Dataset Information

Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.

Objective

Methods

Results

Conclusions

Clinicaltrialsgovidentifier

Classification of evidence

Publications

Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.

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