A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines.

ABSTRACT: The metabolic phenotype of cancer cells is reflected by the metabolites they consume and by the byproducts they release. Here, we use quantitative, extracellular metabolomic data of the NCI-60 panel and a novel computational method to generate 120 condition-specific cancer cell line metabolic models. These condition-specific cancer models used distinct metabolic strategies to generate energy and cofactors. The analysis of the models' capability to deal with environmental perturbations revealed three oxotypes, differing in the range of allowable oxygen uptake rates. Interestingly, models based on metabolomic profiles of melanoma cells were distinguished from other models through their low oxygen uptake rates, which were associated with a glycolytic phenotype. A subset of the melanoma cell m

SUBMITTER: Aurich MK 

PROVIDER: S-EPMC5570491 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature