IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E₂ during Lung Fungal Infection.

ABSTRACT: Members of the IL-1 family play protective and regulatory roles in immune defense against the opportunistic mold Aspergillus fumigatus In this study, we investigated the IL-1 family member IL-33 in lung defense against A. fumigatus IL-33 was detected in the naive lung, which further increased after exposure to A. fumigatus in a dectin-1-independent manner. Mice deficient in the receptor for IL-33 (Il1rl1^-/-) unexpectedly demonstrated enhanced lung clearance of A. fumigatus IL-33 functioned as a negative regulator of multiple inflammatory cytokines, as IL-1α, IL-1β, IL-6, IL-17A, and IL-22 were significantly elevated in fungal-exposed Il1rl1^-/- mice. Subsequently, IL-33 administration to normal mice attenuated fungal-induced IL

SUBMITTER: Garth JM 

PROVIDER: S-EPMC5587395 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature