IL-25 Could Be Involved in the Development of Allergic Rhinitis Sensitized to House Dust Mite.

ABSTRACT:

Background and purpose

When house dust mite (HDM), a common allergen, comes into the mucosal membrane, it may stimulate innate immunity. However, the precise role of interleukin- (IL-) 25 in the development of HDM-induced nasal allergic inflammation is still unclear. Therefore, we investigated the role of IL-25 in allergic rhinitis (AR) patients sensitized to HDM.

Methods

To confirm the production of IL-25 in human nasal epithelial cells (HNECs), we stimulated HNECs. IL-25 expression in the nasal mucosa from control, non-AR (NAR) patients, and HDM-sensitized AR patients was assessed using immunohistochemistry, and quantitative reverse transcription PCR. Correlations between IL-25 and other inflammatory markers were explored.

Results

An in vitro study showed significan

SUBMITTER: Kim DW 

PROVIDER: S-EPMC5587973 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature